# DrugPath: Mapping Drug-Target Interaction Networks
> Explore DrugPath, a biomedical tool for drug repurposing that maps direct and indirect drug-target interactions using DepMap, PubChem, and SIGNOR data.

Tags: drug-repurposing, biomedical-data-science, bioinformatics, drug-target-interaction, signaling-pathways, precision-medicine, pharma, health-tech
## DrugPath: Drug-Target Interaction Network
*   **Objective:** Identifying interactions between approved drugs and human proteins/genes for drug repurposing.
*   **Goal:** Make drug repurposing faster and cheaper by scaling analysis beyond manual search and identifying indirect pathway effects.

## Data Sources
*   **DepMap PRISM:** 8,000+ compounds screened across cancer cell lines.
*   **PDBsum:** 3D protein-ligand binding structures.
*   **PubChem:** Physical binding and biological interactions for *Homo sapiens*.
*   **SIGNOR:** Human protein-protein signaling network for upstream analysis.

## Technical Architecture
1.  **Merged Drug Lists:** Unified dataset from DepMap and PDBsum.
2.  **PubChem API:** Automated retrieval of interaction records.
3.  **Interaction Collection:** Physical and biological activity data capture.
4.  **Species Verification:** Validation against UniProt and PDB for human specificity.
5.  **SIGNOR Integration:** Tracing indirect effects (e.g., if Drug A inhibits Protein X and Protein X activates Protein Y, Drug A affects Protein Y).

## Clinical Significance
*   **Personalized Treatment:** Clinicians can query a gene (e.g., Gene X) and receive a ranked list of candidate approved drugs.
*   **Scalability:** Simultaneously works across thousands of drugs and genes.
*   **Direct & Indirect Discovery:** Covers binders and upstream signaling partners without needing new drug development.
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