# Alginate-Based NDDS for Geriatric Drug Delivery Thesis
> Pharma research on multiparticulate alginate systems for Pantoprazole, Cod Liver Oil & Calcium Citrate delivery in geriatric patients using ionotropic gelation.

Tags: pharmaceutics, ndds, geriatric-medicine, alginate-beads, pantoprazole, cod-liver-oil, drug-delivery, research-thesis
## NDDS Formulation of Pantoprazole, Cod Liver Oil & Calcium Citrate
* Presentation of M.Pharma Thesis (2025) from Lords University, Alwar.
* Focus: Multiparticulate Alginate System for Geriatric Patients.

## Geriatric Challenges in Drug Delivery
* Physiological factors: Reduced gastric motility, decreased gastric acid, and slower metabolism.
* Physical factors: Dysphagia (difficulty swallowing) and polypharmacy risks.

## Drug Profiles
* **Pantoprazole**: Proton Pump Inhibitor (PPI) used for gastroprotection; acid-labile and requires gastric protection.
* **Cod Liver Oil**: Rich in Omega-3 (EPA/DHA), Vitamin A & D; susceptible to oxidation.
* **Calcium Citrate**: Supports bone health; acid-independent absorption.

## Methodology: Ionotropic Gelation
* Preparation of microspheres and emulsion beads using Sodium Alginate and CaCl2 as a cross-linker.
* Optimization using a 3² Full Factorial Design (DoE).

## Key Research Results
* **Particle Size**: 660–820 µm range.
* **Entrapment Efficiency**: 68.5–81.5%.
* **Drug Release**: Sustained release over 12+ hours.
* **Optimization**: Runs 20 & 21 showed best performance with ~81% entrapment and ~65% drug release.

## Conclusion
* Successful development of a combined pharmaceutical and nutraceutical delivery system.
* Alginate matrix effectively protects Pantoprazole from gastric acid and protects Cod Liver Oil from oxidation.
* Aims to reduce pill burden and improve compliance in elderly populations.
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